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TRK-IN-12

CAT: 0013-GTR19186070-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19186070-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRK-IN-12 (Compound 9e) is a potent macrocyclic TRK inhibitor, effective against the G595R resistance mutation. It shows strong antiproliferative activity in relevant Ba/F3 cell models, outperforming LOXO-101 in the G595R-mutant line. This inhibitor is a valuable tool for studying TRK-driven cancers and resistance mechanisms in both in vitro and in vivo research contexts.
CAS Number
2823342-34-1
Field of Research
Signal Transduction
Smiles
S (CCl) (=O) (=O) N1CC2=C3N (N=C2) C=CC (=N3) N (C) CC=4C (OCC1) =CC=C (F) C4
Molecular Formula
C18H19ClFN5O3S
Molecular Weight
439.89
Storage Conditions
-20°C
Notes
For research use only.

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