TRK-IN-33

CAT: 0013-GTR19274365-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19274365-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

TRK-IN-33 is a TRK inhibitor that demonstrates exceptional ability to degrade TRKAG667C (DC50 = 24.69 nM; Dmax > 90%) while not affecting the wild-type protein. It exhibits antiproliferative activity against Ba/F3-LMNA-NTRK1G667C cells carrying NTRK1G667C, with an IC50 of 2.48 nM. TRK-IN-33 effectively inhibits tumor growth in vivo and induces apoptosis in tumor cells without significant toxicity. This compound is suitable for research in NTRK fusion-positive cancers.

Storage Conditions

-20°C

Notes

For research use only.

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