Products for Research Use Only
RegisterLogin

HPK1-IN-7

CAT: 0804-HY-138742-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-138742-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HPK1-IN-7 is a potent, orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) inhibitor (IC50=2.6 nM) with excellent family and kinome selectivity. HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM) . HPK1-IN-7 shows robust efficacy against MC38 syngeneic tumor model in combination with anti-PD1[1].
CAS Number
2320462-65-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-7.html
Purity
99.33
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1OC(C)(C)C2=C1C=CC(NC3=NC=C(C4=NN=CO4)C(N[C@@H](C5=CC=CC=C5)CO)=N3)=C2
Molecular Formula
C24H22N6O4
Molecular Weight
458.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Degnan AP, et al. Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1. ACS Med Chem Lett. 2021;12 (3) :443-450. Published 2021 Feb 19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K1/HPK1; MAP4K3/GLK

Related Products

CatalogName
HY-159905HPK1-IN-54
HY-144091HPK1-IN-24
HY-153362-01HPK1-IN-34
HY-138568-01HPK1-IN-3
HY-145040HPK1-IN-14
HY-160218HPK1-IN-42
HY-163496HPK1-IN-45
HY-179111HPK1-IN-64
HY-177272HPK1-IN-61
HY-172594HPK1-IN-57

Alternative Products

CatalogName
BA6484-10HPK1-IN-7
GTR19275315-01PROTAC HPK1 Degrader-7
YP-W22891-01Mouse HPK1 (HPK1) ELISA Kit
BA6488-10HPK1-IN-4
BA6481-5.1HPK1-IN-3
BA6487-10HPK1-IN-26
T211044-01HPK1-IN-59
T209691-01HPK1-IN-45
T207159-01HPK1-IN-58
T206873-01HPK1-IN-57

Popular Products