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(KO Validated) STAT3 Polyclonal Antibody

CAT: 0866-RD80731A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD80731A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Description
This is a (KO Validated) STAT3 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
ADMIO, ADMIO1, APRF, HIES, STAT3, Stat3
Gene ID
6774
Swiss Prot
P40763
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human STAT3 (NP_644805.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000 IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
83 kDa/87 kDa/88 kDa
Observed Molecular Weight
90 kDa
Host or Source
Rabbit
Isotype
IgG

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