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(KO Validated) STAT3 Polyclonal Antibody

CAT: 763-E-AB-62227-01Size: 60 μLDry Ice: NoHazardous: No
60 μLSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Abbreviation
STAT3
UniProt
P40763
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant fusion protein of human STAT3 (NP_644805.1) .
Target
ADMIO; ADMIO1; APRF; HIES; STAT3; Stat3
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IF
Field of Research
Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Developmental Biology; Signal Transduction; Stem Cells
Purification
Affinity purification
Concentration
1mg/mL
Dilution
WB 1:500-1:2000; IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
83kDa/87kDa/88kDa
Observed Molecular Weight
90kDa
Citation 01
https://www.frontiersin.org/articles/10.3389/fendo.2018.00574/full
Isotype
IgG

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