Products for Research Use Only
RegisterLogin

STAT3 Antibody, KO Validated

CAT: 0223-14-190Size: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-14-190Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
NCBI Gene ID
6774
Swiss Prot
P40763
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 640-770 of human STAT3 (NP_644805.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction, Stem Cell, Transcription
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 90kDa
Fragment
IgG
Symbol
STAT3
Positive Control 2
293T
NCBI Official Name
Signal transducer and activator of transcription 3 (acute-phase response factor)
NCBI Organism
Homo sapiens
Other Product Names
STAT3 Antibody: APRF, HIES, APRF, Signal transducer and activator of transcription 3, Acute-phase response factor
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

Related Products

CatalogName
23-252CHD1 Antibody, KO Validated
23-063ITGA2 Antibody, KO Validated
22-517XIAP Antibody, KO Validated
22-018SMARCC1 Antibody, KO Validated
19-887HELLS Antibody, KO Validated
19-885HDAC8 Antibody, KO Validated
19-832GNA13 Antibody, KO Validated
19-812SIRT3 Antibody, KO Validated
19-700DNMT1 Antibody, KO Validated
19-605HADHA Antibody, KO Validated

Alternative Products

CatalogName
GTR18705287-01Stat3 Antibody [Knockout Validated]
27574-01[KO Validated] STAT3 Polyclonal Antibody
MBS9232247-01STAT3 Monoclonal Antibody [Knockout Validated]
RD80731A-01(KO Validated) STAT3 Polyclonal Antibody
CQA9277-01Anti-STAT3 Antibody [KO/KD Validated]
AF5315STAT3 Rabbit Polyclonal Antibody (KO Validated)
E46F69713Stat3 Rabbit Monoclonal Antibody [KD Validated]
GTR18335642-01STAT3 Rabbit mAb [KD Validated] Antibody
AGI1841-100KD-Validated Anti-STAT3 Rabbit Monoclonal Antibody
AGI1896-100KD-Validated Anti-STAT3 Mouse Monoclonal Antibody

Popular Products