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STAT3 Rabbit mAb [KD Validated] Antibody

CAT: 0013-GTR18335642-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18335642-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Transcription factor that binds to the interleukin-6 (IL-6) -responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.
Product Name Alternative
APRF; Acute-phase response factor; Signal transducer and activator of transcription 3; STAT3; HIES
UniProt
P40763
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human STAT3
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Cancer Biology
Purification
Affinity-chromatography
Dilution
WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
Form
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
ICC, IHC, WB
Host or Source
Rabbit
Isotype
Rabbit IgG

UniProtKB · P40763

Signal transducer and activator of transcription 3

STAT3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P40763
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
STAT3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K7B8, K7ENL3, O14916, Q9BW54
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Disease

Diabetes mellitusDisease variantDwarfism

Biological process

Host-virus interactionTranscriptionTranscription regulation

Domain

SH2 domain

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