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(KO Validated) STAT5B Polyclonal Antibody

CAT: 0866-RD89435A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD89435A-01Size:60 μL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL) . The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Description
This is a (KO Validated) STAT5B Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
STAT5B, STAT5, signal transducer and activator of transcription 5B
Gene ID
6777
Swiss Prot
P51692
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human STAT5B
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:100, IF 1:50-1:200
Buffer
PBS with 0.05% proclin300,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
62kDa/77kDa
Observed Molecular Weight
Refer to figures
Host or Source
Rabbit
Isotype
IgG

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