AMG-337

CAT: 0804-HY-18696-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18696-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG-337 is a potent, orally active, selective MET kinase inhibitor with IC50 values of 1, 1, 4.7, 5, 21.5, 1077 and >4000 nM of WT MET, H1094R MET, M1250T MET, HGF-stimulated pMET (PC3 cells) MET, V1092I MET, Y1230H MET, and D1228H MET, respectively. AMG 337 inhibits the phosphorylation of MET and downstream effectors in MET-amplified cancer cell lines, resulting in an inhibition of MET-dependent cell proliferation and induction of apoptosis[1][2].
CAS Number
[1173699-31-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Caspase; c-Met/HGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AMG-337.html
Purity
99.40
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(N=CC(OCCOC)=C2)C=CN1[C@@H](C3=NN=C4C(F)=CC(C5=CN(C)N=C5)=CN43)C
Molecular Formula
C23H22FN7O3
Molecular Weight
463.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Hughes PE, et, al. In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models. Mol Cancer Ther. 2016 Jul;15 (7) :1568-79.|[2]Du Z, et, al. Preclinical Evaluation of AMG 337, a Highly Selective Small Molecule MET Inhibitor, in Hepatocellular Carcinoma. Mol Cancer Ther. 2016 Jun;15 (6) :1227-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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Alternative Products

CatalogName
204320AMG-337
TRC-A576575-10MGAMG 337
A16400-2AMG 337 2mg
MF-0062704-01AMG-337 monohydrate
A16400-10AMG 337 10mg
A16400-25AMG 337 25mg
A16400-100AMG 337 100mg
A16400-1AMG 337 1mg
A16400-200AMG 337 200mg
A16400-5AMG 337 5mg

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