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AMG 7905

CAT: 0804-HY-113654Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-113654Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG 7905 is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin[1][2].
CAS Number
1026876-55-0
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/amg-7905.html
Purity
90.93
Smiles
FC(F)(C1=CC(NCC2CCCCC2)=C(C3=CC(NC4=CC5=C(N=CS5)C=C4)=NC=N3)C=C1)F
Molecular Formula
C25H24F3N5S
Molecular Weight
483.55
References & Citations
[1]Garami A, et al. TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development. Acta Physiol (Oxf) . 2018 Jul;223 (3) :e13038.|[2]Lehto SG, et al. Antihyperalgesic effects of (R, E) -N- (2-hydroxy-2,3-dihydro-1H-inden-4-yl) -3- (2- (piperidin-1-yl) -4- (trifluoromethyl) phenyl) -acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats. J Pharmacol Exp Ther. 2008 Jul;326 (1) :218-29.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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