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RecombinantCNTF, Human

CAT: 0013-GTR18991957-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18991957-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor β subunit, and a CNTF specific α receptor subunit. Upon binding to the CNTF, the β subunit of the CNTF receptor will undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons.Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Product Name Alternative
Ciliary Neurotrophic Factor
Source
Escherichia coli.
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE and HPLC.
Bioactivity
ED50 5x10ˆ3 units/mg.
Form
Lyophilized after extensive dialysis against PBS.
Molecular Weight
22.8 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant human Ciliary Neurotrophic Factor (rhCNTF) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhCNTF remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O or PBS at 100 μg/ml.
Preservative
Lyophilized after extensive dialysis against PBS.
AA Sequence
AFT EHSPLTPHRR DLCSRSIWLA RKIRSDLTAL TESYVKHQGL NKNINLDSAD GMPVASTDQW SELTEAERLQ ENLQAYRTFH VLLARLLEDQ QVHFTPTEGD FHQAIHTLLL QVAAFAYQIE ELMILLEYKI PRNEADGMPI NVGDGGLFEK KLWGLKVLQE LSQWTVRSIH DLRFISSHQT GIPARGSHYI ANNKKM

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