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RecombinantCNTF, Rat

CAT: 0013-GTR18991935-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18991935-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ciliary Neurotrophic Factor (CNTF) is a polypeptide hormone which acts within the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. CNTF is a potent survival factor for neurons and oligodendrocytes and may play a role in reducing tissue damage during increased inflammation. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, however this phenotype is not causally related to neurologic disease.Recombinant Rat Ciliary Neurotrophic Factor (CNTF) produced in E .coli is a single, non-glycosylated polypeptide chain of 199 amino acids and a molecular mass of 22.9 kDa. It has been purified by chromatographic techniques.
Product Name Alternative
Ciliary Neurotrophic Factor
Source
Escherichia coli.
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE.
Bioactivity
ED50 < 30ng/ml, measured by its ability to induce alkaline phosphatase production byTF-1 Cells.
Form
Lyophilized after extensive dialysis against 50mM Tris, pH 8.0.
Molecular Weight
22.9 kDa, observed by reducing SDS-PAGE
Storage Conditions
Lyophilized recombinant Rat CNTF remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rrCNTF should be stable up to 1 week at 4°C or up to 3 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O at 100 μg/ml.
Preservative
Lyophilized after extensive dialysis against 50mM Tris, pH 8.0.
AA Sequence
AFAEQTPLTL HRRDLCSRSI WLARKIRSDL TALMESYVKH QGLNKNINLD SVDGVPVAS T DRWSEMTEAE RLQENLQAYR TFQGMLTKLL EDQRVHFTPT EGDFHQAIHT LMLQVSAFA Y QLEELMVLLE QKIPENEADG MPATVGDGGL FEKKLWGLKV LQELSQWTVR SIHDLRVIS S HQMGISALES HYGAKDKQM

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