APP degrader-1

• UNSPSC Description:

  APP degrader-1 (Compound 0152) is an orally active amyloid precursor protein (APP) degrader that induces APP degradation and reduces the extracellular release of Aβ42. APP degrader-1 can bind to both CAPRIN1 and APP, and enhances their interaction as well as CAPRIN1-mediated APP degradation through the endosome-lysosome pathway[1].

• Target Antigen:

  Amyloid-β

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/aβ42-in-5.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C2C(SC(NC(NC3=CC(OC)=CC=C3)=O)=N2)=C1)N4CCOCC4

• Molecular Weight:

  412.46

• References & Citations:

  [1]Jung S, Jaiswal N, Rai R K, et al. Small-molecule degraders reduce Aβ production through CAPRIN1-mediated lysosomal degradation of APP in Alzheimer iPSC-derived neurons[J]. bioRxiv, 2023: 2023.12. 29.573648.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported