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CP-640186

CAT: 0804-HY-15259-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15259-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation[1][2].
CAS Number
591778-68-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Acetyl-CoA Carboxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/CP-640186.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1CN(C2CCN(C(C3=C(C=CC=C4)C4=CC5=C3C=CC=C5)=O)CC2)CCC1)N6CCOCC6
Molecular Formula
C30H35N3O3
Molecular Weight
485.62
Precautions
H302, H315, H319
References & Citations
[1]Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278 (39) :37099-111.|[2]Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21 (21) :6314-8.|[3]Daniel Hess, et al. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One. 2010 Jun 30;5 (6) :e11394.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Am J Transl Res. 2019 Nov 15;11 (11) :7104-7114.|bioRxiv. 2024 May 25.|bioRxiv. 2025 Aug 26:2025.08.21.671640.|Cell Death Dis. 2025 Oct 7;16 (1) :715.|Department of Microbiology & Immunology. Seoul National University Graduate School. 2015 Aug. |Front Oncol. 2021 Apr 22:11:665763.|Front Oncol. 2021 Apr 6.|Nat Commun. 2024 Oct 21;15 (1) :9062.|Nutrients. 2021 May 21;13 (6) :1740.|Viruses. 2019 Dec 10;11 (12) :1145.|J Exp Med. 2021 Dec 6;218 (12) :e20210639.

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