ATC0065 (free base)

• UNSPSC Description:

  ATC0065 free base is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC50 of 15.7 nM for human MCHR1. ATC0065 free base does not exhibits significant activity for MCHR2. ATC0065 free base has anxiolytic and antidepressant activities[1].

• Target Antigen:

  5-HT Receptor; MCHR1 (GPR24)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/atc0065-free-base.html

• Smiles:

  CN(C1=NC(N[C@H]2CC[C@H](CC2)NCCC3=C(C=C(C=C3)Br)OC(F)(F)F)=NC4=C1C=CC=C4)C

• Molecular Weight:

  552.43

• References & Citations:

  [1]Shigeyuki Chaki, et al. Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J Pharmacol Exp Ther. 2005 May;313(2):831-9.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  509145-82-8