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ATC0175

CAT: 0804-HY-107624-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107624-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders[1].
CAS Number
510733-97-8
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H413
Target
MCHR1 (GPR24)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/atc0175.html
Purity
99.84
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN(C1=NC(N[C@H](CC2)CC[C@H]2NC(C(C=C3)=CC(F)=C3F)=O)=NC4=C1C=CC=C4)C.Cl
Molecular Formula
C23H26ClF2N5O
Molecular Weight
461.94
Precautions
H315, H319, H335, H413
References & Citations
[1]Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y. ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 Winter;11 (4) :341-52.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor

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