Cu (II) GTSM

CAT: 0804-HY-139324-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-139324-01Size:5 mg

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Description

Cu (II) GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu (II) GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu (II) GTSM also decreases the abundance of Amyloid-β trimers. Cu (II) GTSM is a potential anticancer and antimicrobial agent[1][2].

CAS Number

68341-14-0

UNSPSC

12352100

Target

Amyloid-β; GSK-3

Type

Reference compound

Related Pathways

Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/cu-ii-gtsm.html

Purity

95.0

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCL; heat to 60°C)

Smiles

CNC1=N[N]2=CC=[N]3N=C(NC)[S-][Cu+2]23[S-]1

Molecular Formula

C6H10CuN6S2

Molecular Weight

293.86

References & Citations

[1]Andres SA, et al. Synthesis, Characterization, and Biological Activity of Hybrid Thiosemicarbazone-Alkylthiocarbamate Metal Complexes. Inorg Chem. 2020;59 (7) :4924-4935.|[2]Crouch PJ, et al. Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. Proc Natl Acad Sci U S A. 2009;106 (2) :381-386.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

GSK-3β

Chemical Information

CuII(gtsm)

CAS Number	68341-14-0
PubChem CID	171378683
IUPAC Name	copper;N-methyl-N'-[2-[[methylamino(sulfido)methylidene]hydrazinylidene]ethylideneamino]carbamimidothioate
Molecular Formula	C6H10CuN6S2-2
Molecular Weight	293.9
Topological Polar Surface Area	75.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Heavy Atom Count	15
Formal Charge	-2
Complexity	247

SMILES

CNC(=NN=CC=NN=C(NC)[S-])[S-].[Cu]

InChI

InChI=1S/C6H12N6S2.Cu/c1-7-5(13)11-9-3-4-10-12-6(14)8-2;/h3-4H,1-2H3,(H2,7,11,13)(H2,8,12,14);/p-2

InChIKey

MNLAJDKBIQOELG-UHFFFAOYSA-L

Chemical Structure

2D Structure

CAS: 68341-14-0

CID: 171378683

Formula: C6H10CuN6S2-2

MW: 293.9

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	293.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	292.970434
Monoisotopic Mass	292.970434
Topological Polar Surface Area	75.5 Å²
Heavy Atom Count	15
Formal Charge	-2
Complexity	247
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	4
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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