Products for Research Use Only
RegisterLogin

BMS-1166

CAT: 0804-HY-102011-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-102011-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[1][2].
CAS Number
1818314-88-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/BMS-1166.html
Purity
99.64
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(O)[C@@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[C@H](O)C1
Molecular Formula
C36H33ClN2O7
Molecular Weight
641.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60 (13) :5857-5867.|[2]Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8 (42) :72167-72181.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-172736-01BMS-986458
HY-14225BMS-764459
HY-145373BMS-986143
HY-115874BMS-753426
HY-15352-01BMS 561390
HY-120625BMS-358233
HY-50883-01BMS 299897
HY-116274-01BMS-8
HY-19837-01BMS-986120
HY-11092-01BMS-509744

Alternative Products

CatalogName
BA6141-5BMS-1166
562218BMS-1166 HCl
A13129-50BMS-1166 50mg
MBS3603361-01BMS-1166 hydrochloride
A13129-200BMS-1166 200mg
A13129-100BMS-1166 100mg
A13129-25BMS-1166 25mg
A13129-1BMS-1166 1mg

Popular Products