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NT-0249 (free base)

CAT: 0804-HY-161297A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161297A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NT-0249 free base is an orally active NLRP3 inhibitor. NT-0249 has anti-inflammatory activity[1].
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nt-0249-free-base.html
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(N=C1)C=C1N(C[C@@H]2CCCO2)S(NC(NC3=C4C(CCC4)=CC5=C3CCC5)=O)(=O)=O
Molecular Formula
C22H29N5O4S
Molecular Weight
459.56
References & Citations
[1]Thornton P, et al. Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796. J Pharmacol Exp Ther. 2024;388 (3) :813-826. Published 2024 Feb 15.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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