NT-0249

• UNSPSC Description:

  NT-0249 is an orally active NLRP3 inhibitor. NT-0249 has anti-inflammatory activity[1]

• Target Antigen:

  NOD-like Receptor (NLR)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/nt-0249.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([N-]S(N(C1=CN(C)N=C1)C[C@@H]2CCCO2)(=O)=O)NC3=C4C(CCC4)=CC5=C3CCC5.[Na+]

• Molecular Weight:

  481.54

• References & Citations:

  [1]Thornton P, et al. Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796. J Pharmacol Exp Ther. 2024 Feb 15;388(3):813-826.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2763617-39-4