NT-0249

• Description :

  NT-0249 is an orally active NLRP3 inhibitor. NT-0249 has anti-inflammatory activity[1]

• UNSPSC :

  12352005

• Target :

  NOD-like Receptor (NLR)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/nt-0249.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([N-]S(N(C1=CN(C)N=C1)C[C@@H]2CCCO2)(=O)=O)NC3=C4C(CCC4)=CC5=C3CCC5.[Na+]

• Molecular Formula :

  C22H28N5NaO4S

• Molecular Weight :

  481.54

• References & Citations :

  [1]Thornton P, et al. Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796. J Pharmacol Exp Ther. 2024 Feb 15;388 (3) :813-826.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NLRP3

• CAS Number :

  [2763617-39-4]