SNAP8719 (free base)

• Description :

  SNAP8719 free base is a selective α1D-adrenoceptor antagonist (pKi = 8.89) . SNAP8719 free base shows affinity for the dopamine D2-, 5-HT1A-, and the human clonal α2a-adrenoceptor, with pKi values of 5.98, 6.47, and [1].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Adrenergic Receptor; Dopamine Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Others

• Smiles :

  O=C(N([C@H](C)CN1CCN(C2=CC(F)=C(F)C=C2F)CC1)C(C3)=O)CC43CCCC4

• Molecular Formula :

  C22H28F3N3O2

• Molecular Weight :

  423.47

• References & Citations :

  [1]Buckner SA, et al. A-315456: a selective alpha (1D) -adrenoceptor antagonist with minimal dopamine D (2) and 5-HT (1A) receptor affinity. Eur J Pharmacol. 2001 Dec 14;433 (1) :123-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT1 Receptor; D2 Receptor; α adrenergic receptor

• CAS Number :

  [255893-38-0]