Products for Research Use Only
RegisterLogin

MI-1061

CAT: 0804-HY-125858-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-125858-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM) . MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity[1].
CAS Number
1410737-34-6
UNSPSC
12352005
Target
Apoptosis; E1/E2/E3 Enzyme; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mi-1061.html
Purity
99.72
Solubility
DMSO : 160 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(NC([C@H](N2)[C@H](C3=CC=CC(Cl)=C3F)[C@]4(C(NC5=C4C=CC(Cl)=C5)=O)C62CCCCC6)=O)C=C1
Molecular Formula
C30H26Cl2FN3O4
Molecular Weight
582.45
References & Citations
[1]Aguilar A, et al. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannichring-opening-cyclization reaction mechanism in spiro-oxindoles. J Med Chem. 2014 Dec 26;57 (24) :10486-98.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-133754MI-1063
HY-D1449-01IR-1061
HY-143218-01TPE-MI
HY-169504MI-4F
HY-117365MI-1481
HY-136360-01MI-3454
HY-136688-01MI-389
HY-133760MI-888
HY-110264MI-192
HY-17493-01MI-773

Alternative Products

CatalogName
BA2856-5MI-1061
MBS5815942MI-1061 TFA
A18450-50MI-1061 50mg
A18450-10MI-1061 10mg
A18450-25MI-1061 25mg
A18450-100MI-1061 100mg
A18450-5MI-1061 5mg
A18450-1MI-1061 1mg
TYD-02774-01(S, R, S) -MI-1061
C8242-50IR-1061

Popular Products