KT-531

• Description:

  KT-531 is a potent and selective inhibitor of HDAC6 with an IC50 of 8.5 nM. KT-531 exhibits strong inhibition against SUP-T11 cells with an IC50 of 0.42 μM. KT-531 can be used in study hematological cancers[1].

• UNSPSC:

  12352005

• Target:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/kt-531.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NO)C1=CC=C(CN(C2CC2)S(=O)(C3=CC(F)=C(F)C(F)=C3F)=O)C=C1

• Molecular Formula:

  C17H14F4N2O4S

• Molecular Weight:

  418.36

• References & Citations:

  [1]Toutah K, et al. Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia. J Med Chem. 2021 Jun 24;64 (12) :8486-8509.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2490284-18-7]