SR-16157

• Description:

  SR-16157 (NSC 732011; HLX-801) is a dual-action steroid sulfatase (STS) inhibitor (IC50 = 0.1 uM) and selective ERα modulator. SR-16157 exhibits STS inhibitory and anti-estrogenic effects in breast cancer cells. SR-16157 may be used in breast cancer research[1].

• Product Name Alternative:

  NSC 732011; HLX-801

• UNSPSC:

  12352005

• Target:

  Estrogen Receptor/ERR; Steroid Sulfatase

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Smiles:

  O=S(OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](CCOCCN(CC)CC)CC[C@@]4([H])[C@]3([H])[C@H](C)CC2=C1)(N)=O

• Molecular Formula:

  C27H44N2O4S

• Molecular Weight:

  492.71

• References & Citations:

  [1]Rasmussen LM, et al. A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer. Breast Cancer Res Treat. 2007 Dec;106 (2) :191-203.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  943344-76-1