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Lamotrigine-d3

CAT: 0804-HY-B0495S5Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0495S5Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lamotrigine-d3 is the deuterium labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[2][3].
CAS Number
1132746-94-1
Product Name Alternative
LTG-d3; BW430C-d3
UNSPSC
12352005
Hazard Statement
H301, H319, H336, H361, H362, H410
Target
Autophagy; Sodium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
98.93
Solubility
10 mM in DMSO|DMSO : ≥ 10mg/mL
Smiles
NC1=NC(N)=C(C2=C(Cl)C(Cl)=C([2H])C([2H])=C2[2H])N=N1
Molecular Formula
C9H4D3Cl2N5
Molecular Weight
259.11
Precautions
H301, H319, H336, H361, H362, H410
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27 (5) :490-7.|[3]Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv) . Apr-Jun 201153 (2) :57-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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