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Lamotrigine-13C3

CAT: 0804-HY-B0495S4Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0495S4Size:1 mg
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Description
Lamotrigine-13C3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
CAS Number
1188265-38-4
Product Name Alternative
LTG-13C3; BW430C-13C3
UNSPSC
12352005
Hazard Statement
H301, H319, H336, H361, H362, H410
Target
Autophagy; Sodium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lamotrigine-13c3.html
Solubility
10 mM in DMSO
Smiles
N[13C]1=N[13C](N)=NN=[13C]1C2=C(C(Cl)=CC=C2)Cl
Molecular Formula
C6 13C3H7Cl2N5
Molecular Weight
259.07
Precautions
H301, H319, H336, H361, H362, H410
References & Citations
[1]M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27 (5) :490-7.|[2]Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv) . Apr-Jun 2011;53 (2) :57-62.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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