Lamotrigine

• Description:

  Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].

• Product Name Alternative:

  LTG; BW430C

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H319, H336, H361, H362, H410

• Target:

  Autophagy; Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Lamotrigine.html

• Concentration:

  10mM

• Purity:

  99.98

• Solubility:

  DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

• Smiles:

  NC1=NC(N)=C(C2=CC=CC(Cl)=C2Cl)N=N1

• Molecular Formula:

  C9H7Cl2N5

• Molecular Weight:

  256.09

• Precautions:

  H301, H319, H336, H361, H362, H410

• References & Citations:

  [1]M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27 (5) :490-7.|[2]Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv) . Apr-Jun 2011;53 (2) :57-62.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [84057-84-1]