Lamotrigine-13C2,15N2,d3

Lamotrigine-13C2,15N2,d3

• UNSPSC Description: Lamotrigine-13C2,15N2,d3 is 15N and deuterated labeled Lamotrigine (HY-B0495). Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
• Target Antigen: Autophagy; Isotope-Labeled Compounds; Sodium Channel
• Type: Isotope-Labeled Compounds
• Related Pathways: Autophagy;Membrane Transporter/Ion Channel;Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: N[13CH]1N=[13C](N)C(C2=C(Cl)C(Cl)=C([2H])C([2H])=C2[2H])=[15N][15N]1
• Molecular Weight: 264.09
• References & Citations: [1]M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27(5):490-7.|[2]Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv). Apr-Jun 2011;53(2):57-62.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported