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Lamotrigine-13C3, d3

CAT: 0804-HY-B0495SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0495SSize:1 mg
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Description
Lamotrigine-13C3, d3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, ?focal seizure, et al[1][2].
CAS Number
1246815-13-3
Product Name Alternative
LTG-13C3, d3; BW430C-13C3, d3
UNSPSC
12352005
Hazard Statement
H301
Target
Autophagy; Isotope-Labeled Compounds; Sodium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Others
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
N[13C]1=N[13C](N)=NN=[13C]1C2=C(C(Cl)=C([2H])C([2H])=C2[2H])Cl
Molecular Formula
C6 13C3H4D3Cl2N5
Molecular Weight
262.09
Precautions
P264-P270-P330-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27 (5) :490-7.|[3]Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv) . Apr-Jun 2011;53 (2) :57-62.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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