MRT-14

CAT: 0804-HY-145918-04Size: 100 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-145918-04Size:100 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling[1].

CAS Number

1263131-83-4

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Smo

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mrt-14.html

Purity

98.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1)NC2=CC=CC(NC(NC(C3=CC(OC)=C(C(OC)=C3)OC)=O)=N)=C2

Molecular Formula

C24H24N4O5

Molecular Weight

448.47

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Manetti F, et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol Pharmacol. 2010;78 (4) :658-665.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

N-(N-(3-Benzamidophenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide

CAS Number	1263131-83-4
PubChem CID	136210502
IUPAC Name	N-[N'-(3-benzamidophenyl)carbamimidoyl]-3,4,5-trimethoxybenzamide
Molecular Formula	C24H24N4O5
Molecular Weight	448.5
XLogP	3.5
Topological Polar Surface Area	124
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Heavy Atom Count	33
Formal Charge	0
Complexity	668

SMILES

COC1=CC(=CC(=C1OC)OC)C(=O)NC(=NC2=CC=CC(=C2)NC(=O)C3=CC=CC=C3)N

InChI

InChI=1S/C24H24N4O5/c1-31-19-12-16(13-20(32-2)21(19)33-3)23(30)28-24(25)27-18-11-7-10-17(14-18)26-22(29)15-8-5-4-6-9-15/h4-14H,1-3H3,(H,26,29)(H3,25,27,28,30)

InChIKey

CIWMWTKJZQOXBC-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1263131-83-4

CID: 136210502

Formula: C24H24N4O5

MW: 448.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	448.5
XLogP3	3.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Exact Mass	448.17466988
Monoisotopic Mass	448.17466988
Topological Polar Surface Area	124 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	668
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-145387-01	MRT-81
HY-108507-01	MRT-10
HY-175453	MRT-23227
HY-175437	MRT-7612
HY-117903A	MRT-92
HY-153356-01	MRT-2359
HY-175452-01	MRT-3486
HY-175451	MRT-10350
HY-174329	Mrt-5702D
HY-118326	MRT 68601

Alternative Products

Catalog	Name
BA9081-50	MRT-14
BA9077-25	MRT-81
B7685-25	MRT 10
BA2747-10	MRT-2359
574378	MRT-10
T212146-01	MRT-7612
T12109-01	MRT-83
sc-507429	MRT 68921
GTR19239330-01	MRT-92
GTR19237288-01	MRT 199665

MRT-14

Chemical Information

Related Products

Alternative Products

Popular Products