PD-1/PD-L1-IN-31

• UNSPSC Description:

  PD-1/PD-L1-IN-31 is a PD-1/PD-L1 inhibitor (IC50=2.2 nM). PD-1/PD-L1-IN-31 promotes secretion of the IFN-γ, and induces immune activity of peripheral blood mononuclear cells (PBMCs) to inhibits tumor cells[1].

• Target Antigen:

  PD-1/PD-L1

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pd-1-pd-l1-in-31.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CC=CC=C1C2=CC=CC3=C2CC[C@@H]3OC4=NC(OC)=C(CNCCO)C=C4Cl

• Molecular Weight:

  442.91

• References & Citations:

  [1]Cai S, et al. Design, synthesis, and evaluation of PD-1/PD-L1 small-molecule inhibitors bearing a rigid indane scaffold. Eur J Med Chem. 2023 Aug 5;256:115468.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3049472-36-5