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SB-267268

CAT: 0804-HY-19306-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19306-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB-267268 is a selective and nonpeptidic alpha (v) beta3 (αvβ3) and alpha (v) beta5 (αvβ5) integrins antagonist, with Kis of 0.9, 0.5 and 0.7 nM for human αvβ3, monkey αvβ3 and human αvβ5, respectively. SB-267268 inhibits human and mouse αvβ3 with IC50s of 0.68 and 0.29 nM, respectively. SB-267268 reduces angiogenesis and VEGF expression[1].
CAS Number
205678-26-8
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sb-267268.html
Purity
99.85
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(O)C[C@H]1C(N(CC(F)(F)F)CC2=CC(OCCCNC3=NC=CC=C3)=CC=C2C1)=O
Molecular Formula
C22H24F3N3O4
Molecular Weight
451.44
References & Citations
[1]Wilkinson-Berka JL, et al. SB-267268, a nonpeptidic antagonist of alpha (v) beta3 and alpha (v) beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2006 Apr;47 (4) :1600-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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