MK-8245

• Description:

  MK-8245 is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC50s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H410

• Target:

  Stearoyl-CoA Desaturase (SCD)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/MK-8245.html

• Purity:

  99.04

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(CN1N=C(N=N1)C2=CC(N3CCC(CC3)OC4=CC(F)=CC=C4Br)=NO2)O

• Molecular Formula:

  C17H16BrFN6O4

• Molecular Weight:

  467.25

• Precautions:

  H302, H410

• References & Citations:

  [1]Oballa RM, et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.J Med Chem. 2011 Jul 28;54 (14) :5082-96. Epub 2011 Jun 28.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [1030612-90-8]