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HDAC6-IN-37

CAT: 0931-T86557-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T86557-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2986486-82-0
Target
HDAC
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
HDAC6-IN-37 (compound W5), an HDAC6 inhibitor, exhibits neuroprotective properties. It effectively restores the morphology of hippocampal neurons and diminishes the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats. Additionally, it prevents the formation of senile plaques and neurofibrillary tangles. Consequently, HDAC6-IN-37 ameliorates the symptoms in the Aβ/Cu 2+ -induced AD rat model, regulates oxidative stress, and restores balance to neurotransmitter levels in brain tissue [1].
Smiles
C(N1C=2C(SC=3C1=CC=CC3)=CC=CC2)C4=CC=C(C(NO)=O)C=N4.Cl
Molecular Formula
C19H16ClN3O2S
Molecular Weight
385.87
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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