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IL-13 receptor alpha 2 EC

CAT: 0209-101-M479Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M479Size:50 µg
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Description
Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. IL-13 can bind to IL-13 R alpha 1 (CD213a1; previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. Alternately, IL-13 can bind IL-13 R alpha 2 (CD213a2) with high affinity; this interaction does not cause activation of STAT6, but does induce TGF-beta production. IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. IL-13 R subunits can be expressed on monocytes, macrophages, fibroblasts, human B cells, basophils, eosinophils, endothelial cells, and smooth muscle cells.
Synonyms
IL13RA2; CT19; IL-13R; IL13BP; CD213A2
NCBI Gene ID
3598
UniProt
Q14627
Accession Number
NP_000631.1
Accession Number mRNA
NM_000640.2
Chromosomal Location
Xq13.1-q28
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human IL-13R alpha 2 EC domain
Clone
(#11S23)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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GTR18598075-01IL-13 Receptor alpha 1 Rabbit pAb
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BL10570_RRecombinant Human Interleukin 13 Receptor, Alpha 1 (IL-13 Ralpha1)
128392IL13RA2 (Interleukin-13 Receptor Subunit alpha-2, IL-13 Receptor Subunit alpha-2, IL-13R Subunit alpha-2, IL-13R-alpha-2, IL-13RA2, Interleukin 13 Receptor, alpha 2, IL-13R, IL13R, CD213a2, CT19, Interleukin-13-binding Protein, IL13BP)
128395-PEIL13RA2 (Interleukin-13 Receptor Subunit alpha-2, IL-13 Receptor Subunit alpha-2, IL-13R Subunit alpha-2, IL-13R-alpha-2, IL-13RA2, Interleukin 13 Receptor, alpha 2, IL-13R, IL13R, CD213a2, CT19, Interleukin-13-binding Protein, IL13BP) (PE)

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