IL-5R alpha EC

CAT: 0209-101-M792Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M792Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin‑5 Receptor alpha (IL‑5 R alpha), also known as CD125, is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology. Mature human IL‑5 R alpha consists of a 322 amino acid (aa) extracellular domain (ECD) with a WSxWS motif and a four-cysteine motif, a 20 aa transmembrane segment, and a 58 aa cytoplasmic domain. Within the ECD, human IL-5 R alpha shares 71% aa sequence identity with mouse and rat IL‑5 R alpha. Alternate splicing of human IL‑5 R alpha generates soluble secreted forms which function as IL‑5 antagonists. The high affinity receptor for IL‑5 is a complex that consists of the ligand binding IL‑5 R alpha and the transmembrane common beta chain (beta c/CD131) which is shared with the receptor complexes for IL‑3 and GM‑CSF. IL‑5 R alpha binds IL‑5 at low affinity and then associates with preformed beta c oligomers to form the signalling‑competent receptor complex.
Synonyms
Interleukin-5 receptor subunit alpha, IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA, CDw125, CD125
NCBI Gene ID
3568
UniProt
Q01344
Accession Number
NP_000555.2
Accession Number mRNA
NM_000564.4
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant IL-5RalphaEC domain
Clone
(#6J30)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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