IL-12 receptor beta 1 EC

• Description:

  The biological activities of IL-12 are mediated through a receptor complex composed of two class I cytokine receptor subunits designated IL-12 R beta 1 and IL-12 R beta 2. Both subunits are required for high-affinity binding and activity of IL-12. IL-12 R beta 1 binds specifically to IL-12 p40, a subunit of the heterodimeric IL-12, and is also a subunit of the IL-23 receptor complex, while IL-12 R beta 2 binds IL-12 p35. IL-12 Rs are predominantly expressed on NK cells and activated T (Th1) cells with some expression also on dendritic cells. Both IL-12 R subunit extracellular domains are composed of three fibronectin-like domains and two cytokine receptor homology domains. IL-12R beta 2 also has an extracellular Ig-like domain.

• Synonyms:

  IL12RB1; CD212; IL12RB; IL-12R-BETA1

• NCBI Gene ID:

  3594

• UniProt:

  P42701

• Accession Number:

  NP_005526.1

• Accession Number mRNA:

  NM_005535.1

• Chromosomal Location:

  19p13.1

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant human IL-12R alpha 1 EC domain

• Clone:

  (#7V24)

• Applications:

  FC

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG1