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IL-12 receptor beta 1 EC

CAT: 0209-101-M476Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M476Size:100 µg
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Description
The biological activities of IL-12 are mediated through a receptor complex composed of two class I cytokine receptor subunits designated IL-12 R beta 1 and IL-12 R beta 2. Both subunits are required for high-affinity binding and activity of IL-12. IL-12 R beta 1 binds specifically to IL-12 p40, a subunit of the heterodimeric IL-12, and is also a subunit of the IL-23 receptor complex, while IL-12 R beta 2 binds IL-12 p35. IL-12 Rs are predominantly expressed on NK cells and activated T (Th1) cells with some expression also on dendritic cells. Both IL-12 R subunit extracellular domains are composed of three fibronectin-like domains and two cytokine receptor homology domains. IL-12R beta 2 also has an extracellular Ig-like domain.
Synonyms
IL12RB1; CD212; IL12RB; IL-12R-BETA1
NCBI Gene ID
3594
UniProt
P42701
Accession Number
NP_005526.1
Accession Number mRNA
NM_005535.1
Chromosomal Location
19p13.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human IL-12R alpha 1 EC domain
Clone
(#7V24)
Applications
FC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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Alternative Products

CatalogName
MBS6507815-01Interleukin 12 receptor, Beta 2 (IL-12-Rb2, beta 2 IL-12R-beta-2, IL-12 receptor beta-2, Interleukin-12 receptor beta-2 chain)
I8434-50CInterleukin 12 receptor, Beta 2 (IL-12-Rb2 , beta 2 IL-12R-beta-2, IL-12 receptor beta-2, Interleukin-12 receptor beta-2 chain) (APC)
MBS6507814-01Interleukin 12 receptor, Beta 2 (IL-12-Rb2, beta 2 IL-12R-beta-2, IL-12 receptor beta-2, Interleukin-12 receptor beta-2 chain)(APC)
HC99828Human IL-12 Receptor Beta-2
MBS6507812-01Interleukin 12 Receptor, beta 1 (IL-12Rb1, Interleukin-12 Receptor Subunit beta-1, IL-12 Receptor Subunit beta-1, IL-12R Subunit beta-1, IL-12R-beta-1, IL-12 Receptor beta Component, CD212, Il12rb1, Il12rb)(PE)
I8434-49AInterleukin 12 Receptor, beta 1 (IL-12Rb1, Interleukin-12 Receptor Subunit beta-1, IL-12 Receptor Subunit beta-1, IL-12R Subunit beta-1, IL-12R-beta-1, IL-12 Receptor beta Component, CD212, Il12rb1, Il12rb) (PE)
I8434-49Interleukin 12 Receptor, beta 1 (IL-12Rb1, Interleukin-12 Receptor Subunit beta-1, IL-12 Receptor Subunit beta-1, IL-12R Subunit beta-1, IL-12R-beta-1, IL-12 Receptor beta Component, CD212, Il12rb1, Il12rb) (Carboxyfluorescein) discontinued
I8434-49BIL12RB1 (Interleukin-12 Receptor Subunit beta-1, IL-12 Receptor Subunit beta-1, IL-12R Subunit beta-1, IL-12R-beta-1, IL-12RB1, IL-12 Receptor beta Component, CD212, IL12R, IL12RB)
216668Interleukin 12 Receptor Beta 1 (IL-12 R beta1)
128385IL12RB1 (Interleukin-12 Receptor Subunit beta-1, IL-12 Receptor Subunit beta-1, IL-12R Subunit beta-1, IL-12R-beta-1, IL-12RB1, IL-12 Receptor beta Component, CD212, IL12R, IL12RB, MGC34454)

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