IL-20 receptor alpha EC

CAT: 0209-101-M504Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M504Size:100 µg
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Description
IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland. The expression of IL-20 R alpha, together with that of IL-20 R beta, is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells. IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals. IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26. Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes.
Synonyms
IL20RA; IL-20R1; ZCYTOR7
NCBI Gene ID
53832
UniProt
Q9UHF4
Accession Number
NP_055247.3
Accession Number mRNA
NM_014432.2
Chromosomal Location
6q23.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human IL-20 Ralpha EC domain
Clone
(#9F40)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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mAP-0108Rat Monoclonal anti-mouse IL-20 Receptor alpha
MBS2552797-01Recombinant Human IL-20 Receptor Subunit alpha alpha/IL20RA Protein (C-Fc)
223556-01IL-20Ralpha (Interleukin-20 Receptor Subunit alpha, IL-20 Receptor Subunit alpha, IL-20R-alpha, IL-20RA, Cytokine Receptor class-II Member 8, Cytokine Receptor Family 2 Member 8, CRF2-8, IL-20R1, ZcytoR7, UNQ681/PRO1315, IL20RA) discontinued
406574-01IL20RA (Interleukin-20 Receptor Subunit alpha, IL-20 Receptor Subunit alpha, IL-20R-alpha, IL-20RA, Cytokine Receptor class-II Member 8, Cytokine Receptor Family 2 Member 8, CRF2-8, IL-20R1, ZcytoR7, IL20RA, UNQ681/PRO1315)
I8441-75DIL20RA (Interleukin-20 Receptor Subunit alpha, IL-20 Receptor Subunit alpha, IL-20R-alpha, IL-20RA, Cytokine Receptor Class-II Member 8, Cytokine Receptor Family 2 Member 8, CRF2-8, IL-20R1, ZcytoR7, UNQ681/PRO1315) discontinued

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