PF-9366

• Description :

  PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Methionine Adenosyltransferase (MAT)

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/PF-9366.html

• Purity :

  99.94

• Solubility :

  DMSO : 10 mg/mL (ultrasonic)

• Smiles :

  CN(C)CCC1=NN=C2N1C3=CC=C(Cl)C=C3C(C4=CC=CC=C4)=C2

• Molecular Formula :

  C20H19ClN4

• Molecular Weight :

  350.84

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Quinlan CL, et al. Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. Nat Chem Biol. 2017 Jul;13 (7) :785-792.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [72882-78-1]