MSA-2 dimer

• Description :

  MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide[1].

• UNSPSC :

  12352005

• Target :

  STING

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/msa-2-dimer.html

• Purity :

  99.88

• Solubility :

  DMSO : 70 mg/mL (ultrasonic)

• Smiles :

  O=C(CCC(C1=CC2=C(C=C(C(CCCC3=CC4=C(C=C3OC)SC(C(CCC(O)=O)=O)=C4)=C2)OC)S1)=O)O

• Molecular Formula :

  C29H28O8S2

• Molecular Weight :

  568.66

• References & Citations :

  [1]Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369 (6506) :eaba6098.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2377881-92-8]