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MSA-2

CAT: 0804-HY-136927-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136927-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1][2].
CAS Number
129425-81-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/msa-2.html
Purity
99.81
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C(S1)=C2)=CC(OC)=C2OC)CCC(O)=O
Molecular Formula
C14H14O5S
Molecular Weight
294.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369 (6506) :eaba6098.|[2]Liu J, et al. Identification of MSA-2: An oral antitumor non-nucleotide STING agonist. Signal Transduct Target Ther. 2021;6 (1) :18. Published 2021 Jan 12.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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