MSA-2

• Description :

  MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  STING

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/msa-2.html

• Purity :

  99.81

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC(C(S1)=C2)=CC(OC)=C2OC)CCC(O)=O

• Molecular Formula :

  C14H14O5S

• Molecular Weight :

  294.32

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369 (6506) :eaba6098.|[2]Liu J, et al. Identification of MSA-2: An oral antitumor non-nucleotide STING agonist. Signal Transduct Target Ther. 2021;6 (1) :18. Published 2021 Jan 12.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [129425-81-6]