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PBD dimer-2

CAT: 0804-HY-148424-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148424-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA (T/A) TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–agent conjugates (ADCs), and it can be used for the research of cancer[1][2].
CAS Number
145325-57-1
UNSPSC
12352203
Target
ADC Payload; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pbd-dimer-2.html
Concentration
10mM
Purity
98.01
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
O=C1C2=CC(OC)=C(OCCCCCOC3=C(C=C4C(N=C[C@@]5([H])N(CCC5)C4=O)=C3)OC)C=C2N=C[C@@]6([H])N1CCC6
Molecular Formula
C31H36N4O6
Molecular Weight
560.64
References & Citations
[1]Smellie M, et al. Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers. Biochemistry. 2003 Jul 15;42 (27) :8232-9.|[2]Staben LR, et al. Systematic Variation of Pyrrolobenzodiazepine (PBD) -Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates. J Med Chem. 2020 Sep 10;63 (17) :9603-9622.|[3]Howard PW, et al. Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines. WO2005085259
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported

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