Osimertinib dimer

• Description :

  Osimertinib dimer is a dimer of Osimertinib (HY-15772) . Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer[1][2].

• CAS Number :

  [2564638-97-5]

• UNSPSC :

  12352005

• Target :

  Drug Derivative

• Related Pathways :

  Others

• Field of Research :

  Cancer

• Smiles :

  O=C(NC1=CC(NC2=NC(C3=CN(C)C4=C3C=CC=C4)=CC=N2)=C(C=C1N(CC[N+](C)(CCC(NC5=CC(NC6=NC(C7=CN(C)C8=C7C=CC=C8)=CC=N6)=C(C=C5N(CCN(C)C)C)OC)=O)C)C)OC)C=C

• Molecular Formula :

  C56H67N14O4+

• Molecular Weight :

  1000.22

• References & Citations :

  [1]Yuan BZ, et al. Oxitinib dimer, preparation method and application thereof. CN112028880A. |[2]Cross DA, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4 (9) :1046-61.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported