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Afatinib oxalate

CAT: 0931-T64075-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T64075-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1398312-64-5
Target
Others, Apoptosis, Akt, c-Met/HGFR, EGFR, Autophagy
Related Pathways
Others, Cytoskeletal Signaling, JAK/STAT signaling, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Angiogenesis, Apoptosis, Autophagy
Bioactivity
Afatinib (BIBW 2992) oxalate is an irreversible, orally active bispecific inhibitor of the ErbB family (EGFR and HER2) with IC50 values of 0.5 nM for EGFRwt, 0.4 nM for EGFRL858R, 10 nM for EGFRL858R/T790M, and 14 nM for HER2. Afatinib oxalate can be used to study esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC), and gastric cancer.
Smiles
OC(=O)C(O)=O.OC(=O)C(O)=O.CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1
Molecular Formula
C28H29ClFN5O11
Molecular Weight
666.01
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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