Afatinib

• Target:

  C-Met/HGFR|||Autophagy|||EGFR|||Apoptosis|||p38 MAPK|||Akt

• Related Pathways:

  MAPK|||JAK/STAT signaling|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Apoptosis|||Autophagy|||Angiogenesis|||PI3K/Akt/mTOR signaling

• Purity:

  0.999

• Bioactivity:

  Afatinib (BIBW 2992) is an irreversible inhibitor of the EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M, and HER2) with IC50s of 0.5 nM, 0.4 nM, 10 nM, and 14 nM, respectively.

• Smiles:

  N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

• Molecular Formula:

  C24H25ClFN5O3

• Molecular Weight:

  485.94

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  850140-72-6