(S) -Afatinib

• Target:

  P38 MAPK|||Apoptosis|||Akt|||HER|||c-Met/HGFR|||EGFR|||Autophagy

• Related Pathways:

  Cytoskeletal Signaling|||Apoptosis|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||MAPK|||Autophagy

• Purity:

  >99.99%

• Bioactivity:

  (S) -Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, respectively.

• Smiles:

  CN (C) CC=CC (=O) Nc1cc2c (Nc3ccc (F) c (Cl) c3) ncnc2cc1O[C@H]1CCOC1

• Molecular Formula:

  C24H25ClFN5O3

• Molecular Weight:

  485.94

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  439081-18-2