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(S) -Afatinib

CAT: 0931-T2303-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T2303-01Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
439081-18-2
Target
P38 MAPK, Apoptosis, Akt, HER, c-Met/HGFR, EGFR, Autophagy
Related Pathways
Cytoskeletal Signaling, Apoptosis, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, MAPK, Autophagy
Purity
>99.99%
Bioactivity
(S) -Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, respectively.
Smiles
CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1
Molecular Formula
C24H25ClFN5O3
Molecular Weight
485.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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CatalogName
A4746-25Afatinib

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