(R) -Afatinib

• Target:

  C-Met/HGFR|||EGFR|||p38 MAPK|||Others

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Others|||MAPK|||JAK/STAT signaling|||Angiogenesis

• Bioactivity:

  (R) -Afatinib ((R) -BIBW 2992), an isomer of Afatinib, is a potent, orally administered, irreversible inhibitor targeting the ErbB family (EGFR and HER2) with IC50 values of 0.5 nM for EGFR wt, 0.4 nM for EGFR L858R, 10 nM for EGFR L858R/T790M, and 14 nM for HER2, holding potential for research into esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC), and gastric cancer [1].

• Smiles:

  N(C=1C2=C(C=C(O[C@@H]3CCOC3)C(NC(C=CCN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

• Molecular Formula:

  C24H25ClFN5O3

• Molecular Weight:

  485.94

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  439081-17-1