AMG-458

CAT: 0931-T6378-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T6378-02Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

913376-83-7

Target

C-Met/HGFR

Related Pathways

Tyrosine Kinase/Adaptors

Purity

0.9998

Bioactivity

AMG-458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.

Smiles

COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1

Molecular Formula

C30H29N5O5

Molecular Weight

539.58

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Amg-458

CAS Number	913376-83-7
PubChem CID	24764449
IUPAC Name	1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yl)oxy-2-pyridinyl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide
Molecular Formula	C30H29N5O5
Molecular Weight	539.6
XLogP	4
Topological Polar Surface Area	117
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	8
Heavy Atom Count	40
Formal Charge	0
Complexity	951

SMILES

CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC

InChI

InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)

InChIKey

GLBZSOQDAOLMGC-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 913376-83-7

CID: 24764449

Formula: C30H29N5O5

MW: 539.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	539.6
XLogP3	4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	8
Exact Mass	539.21686904
Monoisotopic Mass	539.21686904
Topological Polar Surface Area	117 Å²
Heavy Atom Count	40
Formal Charge	0
Complexity	951
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
A8361-10	AMG-458
FA64937-01	AMG 458

AMG-458

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