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AMG 511

CAT: 0931-T14214-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T14214-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1253573-53-3
Target
PI3K
Related Pathways
PI3K/Akt/mTOR signaling
Purity
≥98%
Bioactivity
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks (Kis of 4 nM, 6 nM, 2 nM, and 1 nM for PI3Kα, β, δ, and γ, respectively), exhibiting anti-tumor activity in a mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling as indicated by a decrease in p-Akt (Ser473) .
Smiles
COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@H](C)N2CCN(CC2)S(C)(=O)=O)cc1F
Molecular Formula
C22H28FN9O3S
Molecular Weight
517.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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