AMG 511

• Target:

  PI3K

• Related Pathways:

  PI3K/Akt/mTOR signaling

• Purity:

  ?98%

• Bioactivity:

  AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks (Kis of 4 nM, 6 nM, 2 nM, and 1 nM for PI3K?, ?, ?, and ?, respectively), exhibiting anti-tumor activity in a mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling as indicated by a decrease in p-Akt (Ser473) .

• Smiles:

  COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@H](C)N2CCN(CC2)S(C)(=O)=O)cc1F

• Molecular Formula:

  C22H28FN9O3S

• Molecular Weight:

  517.58

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1253573-53-3