AMG-458

• CAS Number :

  913376-83-7

• Target :

  C-Met/HGFR

• Related Pathways :

  Tyrosine Kinase/Adaptors

• Purity :

  0.9998

• Bioactivity :

  AMG-458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.

• Smiles :

  COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1

• Molecular Formula :

  C30H29N5O5

• Molecular Weight :

  539.58

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C